Abstract Deadline : Sep. 15
Oral presentation will be selected after evaluation by the scientific committee, but can be recommended for poster presentation.
Application for Young Investigators Award
The organizing committee will provide the Travel Award (USD 800 for recipients from Asia Pacific regions; USD 1,500 for those from US, Canada, Europe, and Africa) for students, postdocs, medical trainees and other young investigators with age under 35. The deadline for Travel Award is Aug. 31.
Applicants should submit a biography, letter of support from their academic advisor/Dean or Department Chair as well as an abstract of their proposed presentation at this meeting. The applicants must register and present their work.
- Instructions for preparing the abstract -
1. Title: Time and Roman, Bold, Plain, Font size 14, Only the first letter of the first word should be typed in capital.
2. Authors: Time & Roman, Plain, Font size 12. Type the full names of all authors with the author presenting the abstract should be indicated by underlining the name. If there are authors with different affiliations, the superscript numbers should be used next to the author names.
3. Affiliations: Time & Roman, Italic, Font size 12, Different affiliations can be indicated by the superscript numbers placed before the institution names
4. Main text: Time & Roman, Plain, Font size 12. Limit the word no more than 250. No figures or tables allowed.
5. Keywords: Provide 3 to 5 keywords below the abstract. Keywords are separated by semin-colon
6. Abstract should be written in a single space except between the title and the author names, between author names and the main body, and between the main body and the keywords
Role of heme oxygenase-1 and its reaction product, carbon monoxide in manifestation of breast cancer stem cell-like properties
Do-Hee Kim1, Hyo-Jin Yoon1, Young-Nam Cha2, and Young-Joon Surh1,3,
1Tumor Microenvironment Global Core Research Center, Seoul National University, Seoul 08826, South Korea
2Department of Pharmacology and Toxicology, College of Medicine, Inha University, Incheon, South Korea
3Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 08826, South Korea
Cancer stem cells (CSCs) constitute a subpopulation of transformed cells that possess intrinsic ability to undergo self-renewal and differentiation, which drive tumor resistance and cancer recurrence. It has been reported that CSCs possess enhanced protection against oxidative stress induced by reactive oxygen species compared with non-stem-like cancer cells. In the present work, we investigated the role of heme oxygenase-1 (HO-1), a representative antioxidant enzyme, on the stemness and self-renewal of human breast CSCs. We found that pharmacologic or genetic inhibition of HO-1 attenuated the sphere formation, whereas HO-1 inducers enhanced the number and the size of tumorspheres in breast CSCs. Carbon monoxide (CO) is endogenously generated as a consequence of degradation of heme by HO-1. The proportion of populations of CD44+/CD24- cells retaining CSC properties was increased in MDA-MB-231 cells treated with a CO-releasing molecule (CORM-2). Following CORM-2 treatment, the expression of Notch-1 and related genes Jagged-1 and Hes-1 was increased, which was accompanied by the mammosphere formation. Taken together, these findings suggest that HO-1-derived CO production stimulates the formation of mammospheres in breast cancer cells through activation of Notch-1 signaling.
Keywords: Cancer stem cells; Carbon monoxide; Heme oxygenase-1; Notch-1; Self-renewal
Poster Panel Size
Please refer to this visualization of the poster panels to be used during the conference. The display area for each poster on the panel of the poster board is 90 cm wide X120 cm long. Please ensure that your poster does not exceed this size. It is recommended that you leave a margin of at least 3 inches (7.5 cm) around the poster. When preparing your poster and considering how much of your display will be visible at eye-level, please bear in mind that panels will be mounted on stands.
Poster Panel Allocation
A numbered panel will be allocated for each poster (separate from the abstract number you have been assigned) and staffs will be on hand at the conference to provide your poster panel number. Please ensure that you stand by your poster(s) during your session for discussion and questions.