Time Subjects Chairs & Speakers
13:00-15:00 Registration
15:00-15:10 Opening Ceremony
15:10-16:00 Opening Keynote Lecture
Sponsored by the Tumor Microenvironment Global Core Research Center of Seoul national University
Chair: Asif Ahmed
The heme oxgenase-biliveridin reductase system: the humble beginnings, the precipitous ascent and the bright future Mahin Maines (USA)
16:00-17:20 Session 1 Heme oxygenase and its master regulator Nrf2 in aging, metabolic/neurodegenerative disorders and cancer
Sponsored by the Medical Research Center of Daegu Haany University
Chair: Shinya Toyokuni & Jung Han Yoon Park
Altered basal and inducible Nrf2-regulated gene expression in aging Henry J. Forman (USA)
Dual roles for Nrf2 and HO-1 in carcinogenesis Young-Joon Surh (Korea)
Role of heme oxygenase-1 in the apolipoprotein A-I-mediated reduction of insulin resistance in pregnant Wistar rats Ben Jing Wu (Australia)
Role of the Nrf2-HO-1 axis in neurohormetic responses for the prevention and treatment of Alzheimer’s disease Jung Hee Jang (Korea)
17:30-20:30 Welcome Reception

Time Subjects Chairs & Speakers
09:00-10:20 Session 2 Heme oxygenase and iron metabolism/disposition Chair: David Stec &
Raekil Park
Heme oxygenase and iron metabolism Prem Ponka (Canada)
HO-1 regulates cellular iron transport and bioenergetics Phyllis Dennery (USA)
Ferroptosis in cancer research Shinya Toyokuni (Japan)
Intracellular iron transfer mediated by the iron chaperone, PCBP2: Formation of a metabolon with heme oxygenase I and cytochrome P450 reductase. Des R. Richardson (Australia)
10:20-10:50 Coffee Break
10:50-11:20 State-of-the-Art Lecture I Chair: Roberto Motterlini
HO-1/CO system expands its territory to metabolism via interorganellar communication Hun Taeg Chung (Korea)
11:20-12:40 Session 3 Physiologic functions of carbon monoxide
Sponsored by the National Creative Research Laboratory for Ca2+ signaling Network, Chonbuk National University
Chair: Libor Vitek &
Chang Duk Jun
Mechanisms of HO-1/CO dependent cytoprotection: from autophagy to inflammasomes Stefan W. Ryter (USA)
Regulation of Ca2+ second messengers formation by CO and NO for insulin secretion in pancreatic β-cells Uh-Hyun Kim (Korea)
Detection and removal of endogenous carbon monoxide in vitro and in vivo by an aqueous hemoprotein model complex Hiroaki Kitagishi (Japan)
Harvesting human islets in carbon monoxide-saturated medium enhances insulin Independence after Islet autotransplantation Hongjun Wang (USA)
12:40-13:40 Lunch & Poster Viewing
13:40-15:00 Session 4 Heme oxygenase in cellular immunity and inflammation
Sponsored by National Creative Research Laboratory/Immune Synapse and Immune Disorder Research Lab., GIST
Chair: Mahin Maines &
Ki Churl Chang
Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation in macrophages Jong-Seok Moon (Korea)
The role of heme oxygenase-1 in the intestinal inflammation Tomohisa Takagi (Japan)
CO-induced TTP resolves acute inflammation by increasing autophagolysosome under microbial sepsis Yeonsoo Joe (Korea)
Heme induces trained immunity Sebastian Weiss (Germany)
15:00-16:00 Poster Discussion (with Refreshments)
16:00-17:15 Young Investigator Session I Chair: Yoshito Kumagai &
Taeg Kyu Kwon
Carbon monoxide controls microglial erythrophagocytosis by regulating CD36 surface expression to reduce the severity of hemorrhagic injury Nils Schallner (Germany)
Identification of marliolide and convallatoxin as novel activator and inhibitor of NRF2/HO-1 axis Young Sam Keum (Korea)
Significance of heme oxygenase-1 and cardiac macrophages in myocardial injury Mateusz Tomczyk (Poland)
Role of KEAP1/Nrf2 mutations in lung stem cells and lung cancers Youngtae Jeong (Korea)
Role of heme oxygenase-1 and Nrf2 in manifestation of breast cancer stem cell-like properties Do-Hee Kim (Korea)
18:30-21:00 Faculty Dinner

Time Subjects Chairs & Speakers
09:00-10:20 Session 5 Regulators/targets of heme oxygenase and its products
Sponsored by the Medical Research Center/TLR (Toll-like receptor) Related Diseases Research Center, Konkuk University
Chair: Henry J. Forman &
Young-Min Park
Toll-like receptor 9 (TLR9) induced IL-10 in macrophages is under the control of a HO-1/CO axis Chhanda Biswas (USA)
ATM inhibits oxidative stress-induced apoptosis by regulating HO-1 expression Hyeyoung Kim (Korea)
Electrophile tuning for the development of new heme oxygenase-1 (HO-1) inducers Sabine Amslinger (Germany)
15-Keto-prostaglandin E2 facilitates efferocytosis through Nrf2-mediated upregulation of HO-1 expression Hye-Kyung Na (Korea)
10:20-10:50 Coffee Break
10:50-11:20 State-of-the-Art Lecture II Chair: Phyllis Dennery
Heme oxygenase in vascular health and disease Roland Stocker (Australia)
11:20-12:40 Session 6 Bilirubin and biliverdin reductase Chair: Miguel Soares &
Ock Jin Park
Loss of biliverdin reductase-A (BVRA) promotes lipid accumulation and lipotoxicity in mouse proximal tubule cells David Stec (USA)
Bilirubinomics 2018 Libor Vitek (Czech Republic)
Bilirubin metabolism and its link to metabolic health Karl-Heinz Wagner (Austria)
The role of heme oxygenase metabolites in regulation of neurovascular function Yoon Kyung Choi (Korea)
12:40-13:40 Lunch & Poster Viewing
13:40-15:00 Session 7 Heme oxygenase in tissue repair, remodeling and protection
Sponsored by the Medical Research Center of Wonkwang University
Chair: Jesus Araujo &
Jeong Woo Park
Heme catabolism in disease tolerance to infection Miguel Soares (Portugal)
Walnut mitigates NSAIDs-associated gastrointestinal damage via HO-1 induction Ki Baik Hahm (Korea)
Interplay between soluble Flt-1, heme oxygenase-1 and microRNAs in preeclampsia Asif Ahmed (UK)
HO-1 in liver transplantation: from bench to bedside Jerzy W. Kupiec-Weglinski (USA)
15:00-16:00 Poster Discussion (with Refreshments)
18:00-21:00 Galla Dinner

Time Subjects Chairs & Speakers
09:00-10:20 Session 8 Heme oxygenase and other mediators of cellular stress response
Cellular Responses to Metabolic Stress Research Center, UNIST
Chair: Karl-Heinz Wagner &
Kwon Moo Park
Relevance of the Nrf2/HO-1 axis in the cardiovascular responses to environmental stresses Jesus Araujo (USA)
Electrophilic stress regulated by reactive sulfur species Yoshito Kumagai (Japan)
Dual-activity molecules targeting the Nrf2/heme oxygenase-1 as anti-inflammatory agents Roberta Foresti (France)
ROS/Nrf2/ARE-dependent HO-1 induction attenuates lung inflammatory diseases Chuen-Mao Yang (Taiwan)
10:20-10:50 Coffee Break
10:50-11:20 State-of-the-Art Lecture III Chair: Leo Otterbein
Heme oxygenase-1 in stem cells: More than cytoprotection Jozef Dulak (Poland)
11:20-12:40 Session 9 Heme oxygenase and Nrf2 in cell differentiation, proliferation and survival Chair: Prem Ponka &
Jong-Sang Kim
Heme oxygenase-1 in embryonic stem cell differentiation Shaw-Fang Yet (Taiwan)
The involvement of RUNX3 in the NRF2-HO1 pathway Jin-Won Hyun (Korea)
S-Nitrosylation of NOX4 prevents oxidative damage and apoptosis of endothelial cells devoid of Nrf2 Anna Grochot-Przeczek (Poland)
Heat shock protein-mediated immunoregulation for prevention and treatment of systemic inflammatory response syndromes (SIRS) David Haines (USA)
12:40-13:40 Lunch
13:40-15:00 Session 10 Clinical aspects of heme oxygenase and its products
Sponsored by the Meta Inflammation Research Institute, University of Ulsan
Chair: Shaw-Fang Yet & Yong Chool Boo
Therapeutic applicability of CO-releasing molecules and detection of CO in biological samples Roberto Motterlini (France)
Organic carbon monoxide prodrugs as research tools and for medicinal applications Binghe Wang (USA)
Role of the heme-heme oxygenase-1 system in inflammation Stephan Immenschuh (Germany)
Haptoglobin is present as zonulin in the brain and its overexpression improves intracerebral hemorrhage (ICH) outcomes Sylvain Doré (USA)
15:00-15:30 Coffee Break
15:30-16:45 Young Investigator Session II Chair: Stefan W. Ryter &
Hong Pyo Kim
Carbon monoxide-induced metabolic switch in adipocytes improves insulin resistance in obese mice Laura Braud (France)
Effects of dihydrolipoic acid on mercury toxicity and heme oxygenase-1 expression in PC12 cells Kaniz Fatima Binte Hossain (Japan)
Genetic deficiency of C5aR2 protects against ischemia-reperfusion-induced kidney injury-role of heme oxygenase (HO)-1 expressing M2-macrophages Vijith Vijayan (Germany)
Targeting mechanisms to better understand the improved lipid and glucose status of mild hyperbilirubinemia. Claudia Anna Lang (Austria)
13-cis-Retinoic acid induces apoptosis by increasing intracellular reactive oxygen species and down-regulating Nrf-2 targeted genes in human cholangiocarcinoma cells Siriwoot Butsri (Thailand)
16:45-17:15 Closing & Award Ceremony